Uji Toksisitas Akut Kulit Manggis (Garcinia mangostana L.) Kajian Histopatologis Hati

Authors

  • Agung Adi Candra Jurusan Peternakan Politeknik Negeri Lampung
  • Nani Irwani Jurusan Peternakan Politeknik Negeri Lampung

DOI:

https://doi.org/10.25181/prosemnas.v0i0.481

Abstract

The purpose of research was to examine the toxicity Acute Mangosteen Skin (Garciniamangostana L.) and Histopathologic Study of Liver. Animals in this study was 2 weeks oldchickens with an average weight of 500 grams were divided into the test group; distilled water (blank), doses of 250, 500.1000, 2000.4000 mg / kg weight tubuh.ayam housed in individual cages and given food and drink adlibitum. Acute toxicity tests performed on experimental animals. Giving the toxic dose in the treatment group performed one (single dosage) by intragastric using a stomach sonde. The control group was force-fed with 1 ml physiological saline. Acute toxicity tests performed on experimental animals. Giving the toxic dose in the treatment group performed one (single dosage) by intragastric using a stomach sonde. The control group was force-fed with 1 ml physiological saline. On histopathological examination of liver in the test toksikasi mangosteen rind extract the microscopic changes that occur are cell degeneration and necrosis of hepatocytes. In the treatment group occurred degeneration that occurs in hepatocyte cell degeneration grained and hidrops. Extract of mangosteen rind has a broad safety index and does not cause high mortality in administration. Mangosteen rind extract that does not cause cellular toxicityreaction in the delivery of 100 dosesKeyword: Mangosteen Skin , Acute Toxicit, and Histopathologic

Downloads

Download data is not yet available.

References

Chaverri, J. P., N.C. Rodriguez., M.O. Ibarra., J.M.P Rojas. 2008. Medicinal Properties of Mangosteen

(Garcinia mangostana). Food and Chem. Tox. 46: 3227-3239.

Cheville 1999 Cheville NF. 1999. Introduction to veterinary pathology. 2 University Press

Harmita, Radji M. 2005. Analisis Hayati. Buku ajar, Edisi kedua. Jakarta. Departemen Farmasi FMIPA,

Universitas Indonesia. Hal. : 47-88

Husadha Y. 1996. Fisiologi dan pemeriksaaan biokimia hati.In: Noer S, Waspadji S, Rachman M, Lesmana

LA, Widodo D, Isbagio H, dkk (editor). Buku ajar ilmu penyakit dalam. Ed 3 volume 1. Jakarta: Balai

Penerbit FK UI.

Moeljanto, R.D., Mulyono. 2003. Khasiat dan Manfaat Daun Sirih, Obat Mujarab dari Masa ke masa.

Agromedia Pustaka; 7-11, Yogyakarta

Published

2017-11-02

Issue

Section

Artikel